Tyrosinase inhibitor activity of coumarin-resveratrol hybrids.

نویسندگان

  • Antonella Fais
  • Marcella Corda
  • Benedetta Era
  • M Benedetta Fadda
  • Maria Joao Matos
  • Elias Quezada
  • Lourdes Santana
  • Carmen Picciau
  • Gianni Podda
  • Giovanna Delogu
چکیده

In the present work we report on the contribution of the coumarin moiety to tyrosinase inhibition. Coumarin-resveratrol hybrids 1-8 have been resynthesized to investigate the structure-activity relationships and the IC(50) values of these compounds were measured. The results showed that these compounds exhibited tyrosinase inhibitory activity. Compound 3-(3',4',5'-trihydroxyphenyl)-6,8-dihydroxycoumarin (8)is the most potentcompound (0.27 mM), more so than umbelliferone (0.42 mM), used as reference compound. The kinetic studies revealed that compound 8 caused non-competitive tyrosinase inhibition.

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عنوان ژورنال:
  • Molecules

دوره 14 7  شماره 

صفحات  -

تاریخ انتشار 2009